| Ararat-Armenia vs Shirak | | 1 | 4-1 |
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| 01 Dec 10:00 |
| Shkendija vs FK Rabotnicki | | 2 | 1-0 |
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| 01 Dec 12:00 |
| Pacos Ferreira vs Felgueiras 1932 | | 2 | 1-1 |
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| 01 Dec 14:00 |
| Shakhtar Donetsk vs Kryvbas KR | +1.5 goals | 1 | 2-2 |
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| 01 Dec 16:00 |
| Adana Demirspor vs Hatayspor | +1.5 goals | 1 | 3-3 |
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| 01 Dec 17:00 |
| Akritas vs AEK Larnaca | | 2 | 1-1 |
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| 01 Dec 17:00 |
| Brondby vs FC Fredericia | +1.5 goals | 2 | 1-3 |
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| 01 Dec 18:00 |
| Jong Ajax vs Vitesse | | 2 | 2-0 |
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| 01 Dec 19:00 |
| Arouca vs SC Braga | | 1 | 0-4 |
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| 01 Dec 20:15 |
| A. Italiano vs Nublense | | 2 | 1-0 |
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| 01 Dec 23:00 |
| Marítimo U23 vs Leixões U23 | | 1 | 0-3 |
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| 02 Dec 11:00 |
| Etar Veliko Tarnovo vs Sportist Svoge | | 2 | 0-3 |
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| 02 Dec 12:00 |
| Huddersfield Town U21 vs Fleetwood Town U21 | | 2 | 1-0 |
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| 02 Dec 13:00 |
| Barnsley U21 vs Cardiff City U21 | +2.5 goals | 2 | 1-1 |
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| 02 Dec 13:00 |
| Academico Viseu U23 vs Rio Ave U23 | | 1 | 2-1 |
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| 02 Dec 15:00 |
| APR vs Etincelles | | 1 | 2-1 |
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| 02 Dec 16:00 |
| St. Pauli II vs VfB Oldenburg | | 2 | 1-1 |
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| 02 Dec 17:30 |
| Doncaster vs Chesterfield | +2.5 goals | 1 | 5-1 |
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| 02 Dec 19:00 |
| Port Vale vs Barnsley | +1.5 goals | 1 | 5-0 |
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| 02 Dec 19:00 |
| St Albans City vs Potters Bar Town | +1.5 goals | 2 | 1-2 |
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| 02 Dec 19:45 |